Research sheds light on genetic variants' impact beyond autism diagnosis NatureMedicine univ_paris_cite autism genetics variants research
By Susha Cheriyedath, M.Sc.Jun 30 2023Reviewed by Lily Ramsey, LLM More than 180 genes have been identified as contributing to autism spectrum disorder . Historically, however, researchers have focused on diagnosing the condition rather than understanding the spectrum of phenotypes these gene interactions can express.
'Autism' is the abbreviation for 'autism spectrum disorder ', a complex neurological and developmental condition that impairs an individual's social interaction, communication, intelligence, and behavior. The World Health Organization estimates that autism affects 10% of the global population. About the study In the present study, researchers reviewed four studies within a meta-analytic framework to elucidate genes present in patients with ASD and their relative contributions to cognitive impairment in undiagnosed individuals with shared European ancestry.
Related StoriesRelationships between autism and biological function were analyzed by evaluating the quantity of gene expression at four different regions of the brain and across eight different periods of fetal development. Finally, magnetic resonance imaging of 21,040 individuals from the UK Biobank, including 1,675 ASD patients, was analyzed to test previous claims that some genes associated with autism could alter brain anatomy.
Surprisingly, high autism PGS scores in diagnosed individuals, while directly proportional to reduced income, are inversely associated with fluid intelligence – the more autistic the individual, the more intelligent they are.
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