Rare predicted loss-of-function variants of type I IFN immunity genes are associated with life-threatening COVID-19 - Genome Medicine

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Rare predicted loss-of-function variants of type I IFN immunity genes are associated with life-threatening COVID-19 - Genome Medicine
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A study published in GenomeMedicine finds that rare autosomal inborn errors of type I interferon-dependent immunity to influenza viruses can underlie critical forms of COVID-19, especially in people below 60 years of age.

American Genome Center, Uniformed Services University of the Health Sciences, Bethesda, MD, USA; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, USA.Department of Pharmacology and Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.NIAID Collaborative Bioinformatics Resource, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research Inc., Frederick, MD, USA.

Peng Zhang, Matthieu Chaldebas, Baptiste Milisavljevic, Paul Bastard, Takaki Asano, Andrés Augusto Arias, Shen-Ying Zhang, Anne Puel, Stephanie Boisson-Dupuis, Bertrand Boisson, Emmanuelle Jouanguy, Jean-Laurent Casanova, Qian Zhang, Laurent Abel & Aurélie Cobat Infectious Diseases and Tropical Medicine Research Center, Shahid Beheshti University of Medical Sciences, Tehran, IranDepartment of Infectious Diseases and Tropical Medicine, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, IranImmunology Department, University Hospital 12 de Octubre, Research Institute imas12 and Complutense University, Madrid, SpainImmunology Department, Hospital Universitario Central de Asturias; Health Research Institute of Principality of...

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