The prevalence of contact allergy triggered by a common product preservative has decreased in Europe while it has increased in North America - the trends are likely driven by regulatory differences. DermTwitter
"Between 2009 to 2018, the global burden of isothiazolinone allergy showed divergent trends between North American and European countries," lead study author
Subsequently, researchers reported a global increase in the prevalence of contact allergy to isothiazolinones, the authors write. Regulatory restrictions on MI in personal care products were implemented in 2013 in Europe and in 2015 in Canada but not in the US.
In Europe, isothiazolinone allergy peaked in 2013 and 2014; MCI/MI positivity reached 7.6% and 5.4% before decreasing to 4.4% and 3.2% in 2017–2018.In Europe, there were 5.5% and 3.4% positive reactions to MI, compared with 15% in North America in 2017–2018.
The authors add that, to their knowledge, the US government does not restrict the use of MCI/MI or MI.
She advised clinicians to ask their patients who may have allergic contact dermatitis whether they have been exposed to products containing these compounds.
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