Patients with COPD who received probiotics showed significant improvements in strength and functional capacity.
At baseline and 16 weeks, the investigators measured handgrip strength, short physical performance battery , gait speed, and appendicular skeletal mass index. In conjunction, six plasma biomarkers characterized intestinal permeability , neuromuscular junction degradation , systemic inflammation , and oxidative stress .
"Our primary finding is that probiotics can improve muscle strength and functional capacity in COPD patients," Karim and colleagues conclude."These effects are at least partly mediated by reduced gut leakage and associated reduction in systemic oxidative stress and chronic inflammation. Additionally, plasma zonulin, claudin-3, and CAF22 may be useful to evaluate the indexes of sarcopenia and functional dependency.
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