The untapped potential of RNA structures univgroningen
) and, consequently, is not restricted to the analysis of co-transcriptional structure changes. Therefore, in Mthe structures of a large pool of randomly generated single-nucleotide sequence variants of an RNA of interest are queried by chemical probing and changes in the reactivity pattern across mutants indirectly inform on the presence of an alternative RNA conformationapproach is that it cannot be scaled up to analyse the entire transcriptome.
, Mutate and map provides an indirect way to deconvolve RNA structure ensembles by randomly generating a large number of single-nucleotide substitution mutants of an RNA of interest, followed by structure probing analysis. Mutations capable of disrupting base-pairing interactions in the wild-type structure, whilst stabilizing alternative folds, will cause a redistribution of the relative abundance of the structures within the ensemble, leading to reactivity changes.
Brasil Últimas Notícias, Brasil Manchetes
Similar News:Você também pode ler notícias semelhantes a esta que coletamos de outras fontes de notícias.
Researchers Have Discovered a Mutation That Significantly Increases LifespanThe study found that faulty RNA processing can result in longer life. RNA is an important information transmitter in our cells and acts as a blueprint for protein production. When freshly formed RNA is processed, introns are removed to produce mature mRNA coding for protein. This cutting is known
Consulte Mais informação »
AP sources: Justice Dept. watchdog probing Mass. US attorneyThe Justice Department’s internal watchdog is investigating the top federal prosecutor in Massachusetts, two people briefed on the matter say. The probe follows U.S. Attorney Rachel Rollins’ appearance at a political fundraiser featuring Jill Biden.
Consulte Mais informação »
Justice Dept. Watchdog Reportedly Probing Mass. US Attorney Rachel RollinsThe investigation was prompted by Rollins' appearance at a political fundraiser featuring first lady Jill Biden.
Consulte Mais informação »
The Whale Trailer: Brendan Fraser Is BackBrendan Fraser is getting major buzz for his performance in ‘The Whale’ - check out the trailer:
Consulte Mais informação »
Black Panther 2 Reviews Call Wakanda Forever Emotional But Uneven EpicBlackPanther WakandaForever reviews are in and, according to critics, the MCU movie is an emotional film when it comes to tackling grief and loss, even if it is a bit uneven in terms of plot and pacing.
Consulte Mais informação »
Fake product reviews slash consumer trust in half: reportThe new release from Bazaarvoice highlights just how important maintaining credible user-generated content (UGC) is for brands' bottom lines.
Consulte Mais informação »