Mature spermatozoa are characterized by an head, midpiece and a long tail for locomotion. Now, researchers have found that a loss of the structural protein ACTL7B blocks spermatogenesis in male mice. The cells can no longer develop their characteristic shape and remain in a rather round form. The animals are infertile.
Mature spermatozoa are characterized by an head, midpiece and a long tail for locomotion. Now, researchers from the University Hospital Bonn and the Transdisciplinary Research Unit"Life & Health" at the University of Bonn have found that a loss of the structural protein ACTL7B blocks spermatogenesis in male mice. The cells can no longer develop their characteristic shape and remain in a rather round form. The animals are infertile.
To investigate the role of the structural protein in spermiogenesis, Prof. Schorle's team generated a mouse model with a mutation in theusing gene-editing technology. This results in a complete loss of function of ACTL7B."Without ACTL7B, development is blocked, the cells often remain in a roundish shape, usually do not form the elongated, typical sperm shape and die to a large extent ," says first author Gina Esther Merges, a doctoral student in Professor Schorle's laboratory.
Researchers investigated how intestinal stem cells are controlled at the molecular level to remain stem cells or to develop into one of various intestinal cells. By studying mice lacking the protein ... Current tests for male fertility include measuring the concentration and motility of spermatozoa. However, other characteristics of sperm, such as their ability to follow a chemical trail to the egg, ...
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