New therapeutic target for osteoarthritis identified northwesternu NatureComms
Weight-bearing asymmetry
Weight bearing asymmetry was assessed utilizing a custom voluntarily accessed static incapacitance method where mice were trained to perform a string-pulling taskwhile freely standing on a static incapacitance meter platform. To accustom mice to the task, a training phase and a testing phase were necessary. The night before each phase, food was removed to increase motivation to the task.
Clozapine-N-oxide or vehicle ) was administered to test the effect of neuronal inhibition on knee hyperalgesia in Piezo2-Pdi male mice 9 weeks after DMM surgery . Mice were acclimated to testing 8 weeks after DMM surgery.
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