The announcement comes days before an FDA advisory committee meeting to discuss whether to offer updated boosters to Americans this fall.
expected this fall and winter.
Pfizer and its partner BioNTech studied two different ways of updating their shots — targeting just omicron, or a combination booster that adds omicron protection to the original vaccine. They also tested whether to keep today’s standard dosage — 30 micrograms — or to double the shots’ strength. In a study of more than 1,200 middle-aged and older adults who’d already had three vaccine doses, Pfizer said both booster approaches spurred a substantial jump in omicron-fighting antibodies.
“Based on these data, we believe we have two very strong omicron-adapted candidates,” Pfizer CEO Albert BourlaBut many experts say combination shots may be the best approach because they would retain the proven benefits of the original Covid-19 vaccine while adding new protection against omicron. And Pfizer said a month after people received its combo shot, they had a 9 to 11-fold increase in omicron-fighting antibodies. That’s more than 1.
And importantly, preliminary lab studies show the tweaked shots also produce antibodies capable of fighting omicron’s genetically distinct relatives named BA.4 and BA.5, although those levels weren’t nearly as high.
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