Nature research paper: Pan-cancer whole-genome comparison of primary and metastatic solid tumours
. In our study we only considered A and B levels of evidence, which represent variants that have been FDA approved for treatment and are currently being evaluated in a late-stage clinical trial, respectively. A variant was determined to be ‘on-label’ when the cancer type matches the cancer type for which the treatment was approved for or is being investigated for, and ‘off-label’ otherwise. Only actionable variants of the sensitive category were considered .
Treatments were grouped according to their mechanism of action so that multiple drugs with a shared mechanism of action were grouped into the mechanistic treatment category . We created 323 treatment and cancer-type groups by grouping patients with treatment annotation according to their treatment record before the biopsy. One patient might be involved in multiple groups if they have received multiple lines of therapy or a simultaneous combination of multiple drugs.
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