Ovarian cancer study identifies key genes for potential treatments imperialspark CellRepMed
such as T cells and antibodies. But TLS, which are in some ways similar to"normal" lymphatic tissues, are being found by researchers in different types of tumors.
Lead researcher Dr. Haonan Lu, from the Department of Surgery and Cancer, said,"People tend to think of all cancer cell activity as purely malignant—but the reality is less clear-cut. Tumors can hijack a number of normal body processes and here, they seem to be hijacking the formation of normal human lymph tissue within themselves. Some of these lymphoid structures are able to then mature and activate T cells, which could attack the cancer itself.
The team was able to pinpoint the relevant genetic mutations involved in the cancer's TLS formation, some of which are known to have immune-suppressing functions. The researchers found that copy mutations in the genes IL15 and CXCL10 in HGSOC can inhibit the lymphoid tissue forming. They also found that another set of genes, including DCAF15, plays a role in interacting with the TLS tissues after they have been formed, probably making them more or less active.treatment.
Although CT scans form part of standard treatment of the condition, TLS tissues are not visible to the human eye from a normal CT scan. But the research team has developed an artificial intelligence algorithm that was trained to detect the structures within the tumors and have successfully tested the algorithm on scans of patients at Hammersmith Hospital, part of Imperial College Healthcare NHS Trust, known to have TLS tissues.
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