Outcome markers in COPD patients with COVID-19 MDPIOpenAccess COPD COVID19 SARSCoV2 outcome markers
By Dr. Liji Thomas, MDAug 8 2023Reviewed by Benedette Cuffari, M.Sc. Conflicting results have been reported on the outcome of coronavirus disease 2019 in patients with pre-existing chronic obstructive pulmonary disease . A recent prospective cohort study published in Diagnostics reports assessed patients with both conditions to try and predict the mortality risk.
Some of the factors that predict high mortality due to COVID-19 include advancing age, pre-existing conditions such as cardiovascular disease, diabetes, hypertension, COPD, cancer, chronic liver or kidney disease, poor mental health, and neurological conditions. Obesity, pregnancy, immunosuppression, and smoking have also been identified as risk factors for severe COVID-19.
Most patients were males, older than 65 years, and diagnosed with cardiovascular disease. About 25% of the study cohort required non-invasive ventilation, with 30% of these individuals eventually requiring mechanical ventilation. Of these 13 patients, nine died during the study period. Patients with a non-invasive ventilation score of -4.5 or less were at a greater risk for non-invasive ventilation in 85% of cases. This score was based on the value obtained from the polymerase chain reaction test for detecting SARS-CoV-2, the number of lung lobes affected, and presence of diabetes.
The invasive ventilation score appeared to have the greatest prediction accuracy among all three scores.
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