Oral semaglutide outperforms other medications in type 2 diabetes treatment, significantly reducing HbA1c and body weight Type2Diabetes Semaglutide HbA1c BodyWeightLoss ClinicalTrial Diabetes_Ther
By Dr. Sanchari Sinha Dutta, Ph.D.Jun 7 2023 A study analyzing the PIONEER trial data claims that orally administered semaglutide is highly effective in reducing glycated hemoglobin and body weight in type 2 diabetes patients.Study: Greater Combined Reductions of HbA1c ≥ 1.0% and Body Weight Loss ≥ 5.0% or ≥ 10.0% with Orally Administered Semaglutide Versus Comparators.
An HbA1c reduction of 1% or more and a body weight reduction of 5% or more are considered vital indicators of successful treatment response in patients with type 2 diabetes. These combined outcomes are associated with a lower risk of diabetes-related complications, including cardiometabolic diseases and chronic kidney disease.
The efficacy of these medicines was assessed across a variety of background therapies, including diet and exercise, metformin, oral anti-diabetic medicines, or insulin. An HbA1c reduction of 1% or more and body weight reduction of 5% or 10% or more were assessed at weeks 26, 52, and 78 to determine treatment efficacy.
Considering the body weight reduction of 10% or more at the end of treatment, a significantly higher treatment response was observed in patients treated with semaglutide compared to that in patients treated with empagliflozin, sitagliptin, or liraglutide.
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