Opinion | Follow Your Nose to Herd Immunity

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Opinion | Follow Your Nose to Herd Immunity
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From WSJopinion: Mucous membranes provide the first line of defense against illness, which is why it can make sense for vaccinated people to wear a mask. But vaccines still reduce the risk of serious illness or death, writes Michael Segal.

The Centers for Disease Control and Prevention’s latest Covid guidelines have many Americans confused. Vaccinated people are supposed to resume wearing masks, lest they contract and spread the virus. Yet unvaccinated people are still strongly urged to get the shots, which are said to be highly effective. How can both these claims be true?immunity protects the inside of the body, including the lungs.

All this has implications for public-health authorities’ determination to achieve herd immunity through vaccination alone. In the Provincetown, Mass., outbreak, which informed the CDC’s recent change in guidelines, viral loads in the nose were “” in the vaccinated and unvaccinated, suggesting that the vaccine’s efficacy against infection in the nose had fallen to zero with the advent of the Delta variant. That would mean herd immunity through vaccination is impossible.

But this data appears to be distorted by ascertainment bias: The vaccinated people who showed up for testing were disproportionately those who were symptomatic. Better-controlled

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