A novel treatment using supercharged immune cells appears to work against tumors in children with a rare kind of cancer.
Hailing a breakthrough in fighting cancer, FDA approves gene therapy that functions as a ‘living drug’
But success in solid tumors has been elusive. The latest study was done by researchers at the Vatican’s Bambino Gesu pediatric hospital in Rome. “They seem to have found a unique combination” to get the modified cells to multiply initially, then last a long time to continue their cancer-killing work, saidDr. Franco Locatelli
said they also added a safety switch to eliminate the cells if a patient had a severe reaction. When one patient had problems, they flipped the safety switch, showing that it worked, although later they determined the patient’s problem was caused by a brain bleed unrelated to the CAR-T cells. Many of the children had a side effect that is common with CAR-T therapy — an immune overreaction called “cytokine release syndrome.” It can be serious, but was mild in most, the researchers reported.
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