Left-arm spinner Liam Patterson-White starred with four for 15 and Dane Paterson took three for 30 as Leicestershire capitulated.
Shan Masood scored 98 and Wayne Madsen an unbeaten 49 as Derbyshire successfully passed their 219-run target.Middlesex had begun the day 117 ahead on 95 for three but slumped to 196 all out with Luis Reece and Anuj Dal finishing with three wickets apiece.
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