The ability to interrogate DNA, proteins and other material in the bloodstream for information about cancers, infectious disease and other conditions is rapidly advancing.
— which can be crucial for diseases like pancreatic cancer that typically aren't diagnosed until later stages when it is more difficult to treat.Do these tests really change someone's chances of survival?
The answer — which depends in large part on the cancer and available treatment for it — could come from large clinical trials on the horizon. Depending on the results of a four-year pilot study — endorsed earlier this month by National Cancer Institute advisers — a follow-on study of nearly 300,000 people over seven to eight years could assess whether early detection with different liquid biopsies saves lives, Philip Castle, director of the NCI Division of Cancer Prevention recentlyThe field needs better proxies for understanding if a test is ultimately saving lives rather than waiting many years for an answer, says Nickolas...
He acknowledges the risks of overtreating based on early detection but "what is the alternative?" he says, especially for cancers that aren't typically caught until their later stages.
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