New study links perfluoroalkyl substance exposure to childhood asthma phenotypes eBioMedicine asthma childhoodasthma childhealth perfluoroalkyl research news
By Tarun Sai LomteJul 13 2023Reviewed by Lily Ramsey, LLM A recent study published in the eBioMedicine Journal evaluated the effects of exposure to perfluoroalkyl substances on asthma phenotypes.
PFOA or PFOS exposure has been studied regarding childhood asthma. Recently, a meta-analysis showed increased risks of atopic dermatitis and allergic rhinitis due to PFOS and PFOA, respectively, but associations with asthma were inconsistent. Related StoriesUsing untargeted plasma metabolomics, the relative abundance of PFOA and PFOS was measured in blood samples of pregnant individuals at gestational weeks 24 and one week postpartum and children at six months, 18 months, and six years. Subsequently, 48 samples were quantified for PFOA and PFOS levels using targeted re-analysis and calibration pipeline.
Findings Valid PFOS and PFOA measurements were available for 727 and 684 females at gestational week 24 and one week postpartum, respectively. Similarly, 602, 606, and 513 children had valid measures at six months, 18 months, and six years, respectively.
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