The team achieved this by creating a photosensitive hydrogel material, meaning its physical properties will change when exposed to light.
The research team consisted of scientists from the University of Padova in Italy and NIHR Great Ormond Street Hospital Biomedical Research Centre in London.Typically when researchers work with organoids – small 3D structures that mimic the structure and function of real organs – the composition, mechanical properties, and geometric constraints of the hydrogel are typically fixed at the initial time of fabrication.
The photosensitive hydrogel can now be selectively solidified in real-time, allowing them to shape the hydrogel material and create precise structures within the organoids. This process of cross-linking photosensitive hydrogels via two-photon absorption allows them to solidify and shape the hydrogel material, giving them complete control over the growth and behavior of the organoids.
Defined shapes: They created complicated hydrogel molds to direct organoid growth to mimic the intricate architecture of growing intestines. This involved the creation of structures, such as villi and crypts.
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