itemprop=description content=Can particles as minuscule as viruses be detected accurately within a mere 5 minutes? Osaka Metropolitan University scientists say yes, with their innovative method for ultrafast and ultrasensitive quantitative measurement of biological nanoparticles, opening doors for early diagnosis of a broad range of diseases.
Reviewed by Lily Ramsey, LLMOct 6 2023 Can particles as minuscule as viruses be detected accurately within a mere 5 minutes? Osaka Metropolitan University scientists say yes, with their innovative method for ultrafast and ultrasensitive quantitative measurement of biological nanoparticles, opening doors for early diagnosis of a broad range of diseases.
Nanoscale extracellular vesicles including exosomes, with diameters of 50–150 nm, play essential roles in intercellular communication and have garnered attention as biomarkers for various diseases and drug delivery capsules. Consequently, the rapid and sensitive detection of nanoscale EVs from trace samples is of vital importance for early diagnosis of intractable diseases such as cancer and Alzheimer's disease.
A research team led by Director Professor Takuya Iida, Deputy Director Associate Professor Shiho Tokonami, and Assistant Director Professor Ikuhiko Nakase, from the Research Institute for Light-induced Acceleration System at Osaka Metropolitan University, has utilized the power of laser light to accelerate the reaction between nanoscale EVs derived from cancer cells and antibody-modified microparticles.
This research achievement provides a method for ultrafast and ultrasensitive quantitative measurement of biological nanoparticles, offering a foundation for innovative analysis of cell-to-cell communication and early diagnosis of various diseases in the future."Source:Osaka Metropolitan University
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