An analysis published in BMCPregnancyChildbirth identifies six high-priority candidate medicines for preventing spontaneous preterm birth and four high-priority candidate medicines for the management of preterm labor, which warrant further R&D.
]. To overcome these barriers, broader international coordinated efforts around high potential candidates is needed. Successful strategies have been implemented to overcome similar barriers in the development of medicines for children. For example, in 2007, “Paediatric Investigation Plans” were introduced by the European Union, obliging companies applying for licences for new medicines to present a plan to study the medicine in children .
]. There remains an urgent need for large trials for candidate medicines for the prevention of preterm birth and the management of spontaneous preterm labor, which are adequately powered for clinically relevant neonatal outcomes.We have developed a novel, drug-agnostic approach for analysing the R&D pipeline for medicines for spontaneous preterm birth and preterm labor.
]. As advances are made in the understanding of the causes of preterm birth the TPP, a living document, and the pipeline analysis can be updated to address additional pathologies.Over the last 20 years R&D for preterm birth/labor medicines is an active area compared to other maternal conditions. However, many candidates, including promising new therapies, are currently inactive.
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MitoHiFi: a python pipeline for mitochondrial genome assembly from PacBio high fidelity reads - BMC BioinformaticsBackground PacBio high fidelity (HiFi) sequencing reads are both long (15–20 kb) and highly accurate (| Q20). Because of these properties, they have revolutionised genome assembly leading to more accurate and contiguous genomes. In eukaryotes the mitochondrial genome is sequenced alongside the nuclear genome often at very high coverage. A dedicated tool for mitochondrial genome assembly using HiFi reads is still missing. Results MitoHiFi was developed within the Darwin Tree of Life Project to assemble mitochondrial genomes from the HiFi reads generated for target species. The input for MitoHiFi is either the raw reads or the assembled contigs, and the tool outputs a mitochondrial genome sequence fasta file along with annotation of protein and RNA genes. Variants arising from heteroplasmy are assembled independently, and nuclear insertions of mitochondrial sequences are identified and not used in organellar genome assembly. MitoHiFi has been used to assemble 374 mitochondrial genomes (368 Metazoa and 6 Fungi species) for the Darwin Tree of Life Project, the Vertebrate Genomes Project and the Aquatic Symbiosis Genome Project. Inspection of 60 mitochondrial genomes assembled with MitoHiFi for species that already have reference sequences in public databases showed the widespread presence of previously unreported repeats. Conclusions MitoHiFi is able to assemble mitochondrial genomes from a wide phylogenetic range of taxa from Pacbio HiFi data. MitoHiFi is written in python and is freely available on GitHub ( https://github.com/marcelauliano/MitoHiFi ). MitoHiFi is available with its dependencies as a Docker container on GitHub (ghcr.io/marcelauliano/mitohifi:master).
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Differentiating gastrointestinal tuberculosis and Crohn's disease- a comprehensive review - BMC GastroenterologyGastrointestinal Tuberculosis (GITB) and Crohn’s disease (CD) are both chronic granulomatous diseases with a predilection to involve primarily the terminal ileum. GITB is often considered a disease of the developing world, while CD and inflammatory bowel disease are considered a disease of the developed world. But in recent times, the epidemiology of both diseases has changed. Differentiating GITB from CD is of immense clinical importance as the management of both diseases differs. While GITB needs anti-tubercular therapy (ATT), CD needs immunosuppressive therapy. Misdiagnosis or a delay in diagnosis can lead to catastrophic consequences. Most of the clinical features, endoscopic findings, and imaging features are not pathognomonic for either of these two conditions. The definitive diagnosis of GITB can be clinched only in a fraction of cases with microbiological positivity (acid-fast bacilli, mycobacterial culture, or PCR-based tests). In most cases, the diagnosis is often based on consistent clinical, endoscopic, imaging, and histological findings. Similarly, no single finding can conclusively diagnose CD. Multiparametric-based predictive models incorporating clinical, endoscopy findings, histology, radiology, and serology have been used to differentiate GITB from CD with varied results. However, it is limited by the lack of validation studies for most such models. Many patients, especially in TB endemic regions, are initiated on a trial of ATT to see for an objective response to therapy. Early mucosal response assessed at two months is an objective marker of response to ATT. Prolonged ATT in CD is recognized to have a fibrotic effect. Therefore, early discrimination may be vital in preventing the delay in the diagnosis of CD and avoiding a complicated course.
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Woman who lost 44 pints of blood calls for more donationsNatasha Pollock had an emergency C-section after suffering a rare condition during her pregnancy.
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