Could the DNA from a patient's breast tumor help doctors spot whether stray cancer cells are still in her blood?
-- Could the DNA from a patient's breast tumor help doctors spot whether stray cancer cells are still in her blood?
Senior study author Dr. Muhammed Murtaza, from the Translational Genomics Research Institute in Phoenix, said about one-third of women who have surgery after chemotherapy show no signs of residual cancer. This suggests that the surgery might not have been needed. But right now, there's no way to say for sure whether there are any remaining cancer cells in the blood without performing surgery.
CtDNA is DNA fragments that are shed from the tumor site and then circulate in the blood, the study authors explained. The study team used the test on 33 women, aged 40 to 70, with breast cancer, Murtaza said. Their cancers were diagnosed as stage 1 to 3, and none of the women had cancer that had spread to other parts of their body . The women were followed for several months -- from diagnosis until the time they had surgery to remove their tumor.
"It's feasible now to accurately monitor treatment response in early-stage breast cancer patients, and we're on our way to accurately predicting residual disease in these patients," Murtaza said.
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