A new nanocomplex renders a tumor harmless -- and, on top of that, it trains the immune system to detect and eliminate metastases.
An international research team headed by Dr. Johannes Karges of the Faculty of Chemistry and Biochemistry at Ruhr University Bochum, Germany, has developed nanoparticles that accumulate in cancer cells and eliminate them after being photoactivated. In addition, they label them in such a way that immune cells learn to eliminate similar cells throughout the body. This means that even undetected metastases can be treated.
Together with an international team, he's developed a drug packaged in nanoparticles that are administered into the bloodstream."Tumors grow rapidly and uncontrollably, and their tissue is therefore leaky," he describes."Unlike in healthy tissues, the nanoparticles therefore accumulate in them easily." This also means that the particles preferentially accumulate in tumor cells.At the time of administration, the drug is still ineffective.
The research team proved this active principle in experiments on cancer cells and in animal models. They applied it to effectively treat mice that had been implanted with cells from metastasized and incurable human tumors."Now, we're looking for industrial partners who will help us undertake more in-depth studies," says Johannes Karges. He expects that several more years of development work will be needed before the technology can be widely used in clinical applications.
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