New blood test can detect 'toxic' protein years before Alzheimer's symptoms emerge, study shows PNASNews
But research has shown that the seeds of Alzheimer's are planted years—even decades—earlier, long before the cognitive impairments surface that make a diagnosis possible. Those seeds are
that misfold and clump together, forming small aggregates called oligomers. Over time, through a process scientists are still trying to understand, those"toxic" oligomers of amyloid beta are thought to develop into Alzheimer's.that can measure levels of amyloid beta oligomers in blood samples. As they report in a paper published the week of Dec.
"What clinicians and researchers have wanted is a reliable diagnostic test for Alzheimer's disease—and not just an assay that confirms a diagnosis of Alzheimer's, but one that can also detect signs of the disease before cognitive impairment happens.
SOBA, which stands for soluble oligomer binding assay, exploits a unique property of the toxic oligomers. When misfolded amyloid beta proteins begin to clump into oligomers, they form a structure known as an alpha sheet. Alpha sheets are not ordinarily found in nature, andby Daggett's team showed that alpha sheets tend to bind to other alpha sheets.
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