New findings point to a biomarker even more sensitive than D-dimer in detecting risk for VTE in hospitalized patients with COVID-19.
The researchers applied logistic regression and Fine-Gray modeling that accounted for the competing risk for death.The median plasma D-dimer was 1.0 mg/L , whereas the median plasma suPAR was 6.7 ng/mL ., 88 of whom experienced PE, and 10 of whom experienced both.
Of the incident VTE events that took place during 30 days of hospitalization, the cumulative incidence of VTE was 3.5%, 6.0%, and 12.6% for the first, second, and third tertiles of suPAR, respectively Moreover, on the basis of predicted probabilities from random forest, a decision tree identified a subgroup of patients with a combined D-dimer of less than 1 mg/L and suPAR of less than 11 ng/mL who had a 3.6% probability of incident VTE during a COVID-19 hospitalization. This particular subgroup at low risk for VTE represented 41% of the entire study population.
"Companies are developing drugs to target suPAR, and so we might be measuring this on a regular basis," he added.Geoffrey Barnes, MD, MSc, assistant professor of internal, vascular, and cardiovascular medicine, Frankel Cardiovascular Center, University of Michigan, noted that randomized trials have defined the potential impact of treatment-dose anticoagulation for thromboprophylaxis in patients hospitalized with COVID-19.
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