Probiotic bacteria, like elite firefighters heading into the wilderness to combat an uncontrolled blaze, do a better job of quelling gut inflammation when they're outfitted with the finest gear. Just how much promise some well-equipped gut-friendly bacteria hold for improving treatments of inflam
This schematic illustration shows probiotic bacteria coated in a layer of biomaterial as they travel through a human intestine. Attached to the bacteria are reactive oxygen species nano-scavengers. Credit: Quanyin Hu
The research builds on technology the team, led by Quanyin Hu, a biomedical engineer and professor in the UW–Madison School of Pharmacy, had While the root causes of IBD are complex and still being studied, one culprit involves the overproduction of molecules known as reactive oxygen species. Although these molecules are crucial for certain human body functions, too many of them in the gut can fuel damaging inflammation along the lining of the intestines.. The acid is powerfully anti-inflammatory, and the sulfide directly targets the reactive oxygen species.
“That’s the most exciting part of this research for me,” says Hu. “We didn’t want to target a specific IBD stage. We wanted to select the most important factors that contribute to curing or treating the disease at whatever stage.”
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