The presence of a super strain of hyaluronic acid could provide clues into how humans can stave off cancer - and live longer
Rats, viewed the world over as disease-ridden pests, consistently get a bad rap when it comes to health. But a groundbreaking experiment may be about to shake up the way the public views rodents – as they could help us live longer.
They achieved this by inserting the acid synthase 2 gene from the naked mole-rat into 90 ordinary mice, creating supermice that display stronger resistance to cancer and live longer.journal, the genetically modified mice lived 4.4 per cent longer on average, with a 12 per cent increase in maximum life span, compared to mice who did not receive the gene.
The mole-rat’s remarkable resistance to tumours was discovered 10 years ago, when scientists found its cells produce hyaluronic acid, a chemical popular in skincare, which is more than five times more potent than that produced by humans or mice. She is already looking for strategies to safely increase the presence of it in humans. “Transgenesis could be done, administering the [naked mole-rat] genes into adult human tissues using vectors [viruses, for example] or nanoparticles,” she told Spanish newspaper El Pais.
“The question 10 years ago was whether high-molecular-mass hyaluronan was enough to reduce the risk of cancer, or whether there were multiple molecular mechanisms involved. From what I see in this work, it is enough”.
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