The findings could help doctors identify cancer patients who would benefit the most from drugs called checkpoint blockade inhibitors. Cancer drugs known as checkpoint blockade inhibitors have proven effective for some cancer patients. These drugs work by taking the brakes off the body’s T c
In this colon tumor, which has a mutation that gives it a high degree of DNA mismatch repair deficiency, T cells have accumulated primarily in the supportive tissues , while very few have infiltrated tumor cells . Credit: Courtesy of the researchers
Some studies have shown that these drugs work better in patients whose tumors have a very large number of mutated proteins, which scientists believe is because those proteins offer plentiful targets for T cells to attack. However, for at least 50 percent of patients whose tumors show a high mutational burden, checkpoint blockade inhibitors don’t work at all.reveals a possible explanation for why that is.
However, subsequent studies of patients who received this drug found that more than half of them did not respond well or only showed short-lived responses, even though their tumors had a high mutational burden. The MIT team set out to explore why some patients respond better than others, by designing mouse models that closely mimic the progression of tumors with high TMB.
In further experiments, the researchers explored what happened as they changed the heterogeneity of lung tumors in mice. They found that in tumors with clonal mutations, checkpoint blockade inhibitors were very effective. However, as they increased the heterogeneity by mixing tumor cells with different mutations, they found that the treatment became less effective.
Brasil Últimas Notícias, Brasil Manchetes
Similar News:Você também pode ler notícias semelhantes a esta que coletamos de outras fontes de notícias.
Combination of cancer vaccine and T cell therapy benefits patients with advanced ovarian cancerA study has shown that combining adoptive T cell therapy (ACT) with an innovative, personalized cancer vaccine under development can benefit patients with late-stage, drug-resistant ovarian cancer.
Consulte Mais informação »
Alarming Global Cancer Surge: 79% Rise in Cancer Cases Among Those Under 50Global cancer cases in those under 50 surged by 79% over the past 30 years, with breast, windpipe, and prostate cancers leading the rise. The findings call for a global strategy emphasizing prevention, early detection, and tailored treatments for younger patients. There’s been a striking 79% incr
Consulte Mais informação »
Five top crypto stories this past week: New FTX lawsuit, Mt. Gox deadline, investment funds and moreThis week in crypto: Why VC investment in crypto is far from dead, why Web3 in Asia is growing, why ByBit is leaving the UK, and more.
Consulte Mais informação »
Dry weekend aheadA batch of dry air will mix in today, preventing the development of showers and storms.
Consulte Mais informação »
Dodgers mix some fun into their extra-innings walk-off win over GiantsChris Taylor helps turn a run-preventing double play in the 10th inning before driving in the winning run in the Dodgers' 3-2 win over the Giants.
Consulte Mais informação »
'General Hospital' star John J. York battling 2 forms of cancer, staying positive about prognosisLongtime 'General Hospital' star John J. York revealed he is battling two forms of cancer, but he's staying positive and hoping Be The Match can help shine a light on the subject of helping those in need.
Consulte Mais informação »