Multiscale modeling and personalized therapies: tackling the complexities of epilepsy with degeneracy concept CommsBio NaturePortfolio epilepsy multiscale modelling personalised therapy therapies complex degeneracy
By Neha MathurMay 9 2023Reviewed by Lily Ramsey, LLM In a recent article published in the Communications Biology Journal, researchers reviewed epilepsy-related degeneracy at three levels of brain organization: the cellular, network, and systems level.
Degeneracy enables structurally different biological elements to perform the same function or fetch the same output, which allows living organisms to preserve already evolved functions and concomitantly search for new ones. More importantly, delineating the complex interactions underlying epilepsy could help design customized multi-target therapies.
A study of ion channel degeneracy in childhood absence epilepsy presented an interesting example of multiscale modeling, highlighting the need for customized single/multi-target pharmacological therapy. Another simulation study using multiscale network simulations of the spinal dorsal horn provided new insights into the degeneracy of pathological disturbances linked to hyperexcitable neurons present in epileptic patients with chronic pain.
One disadvantage of population modeling is that it fails to show which model parameter combinations from all theoretically feasible spaces occur in real brains.
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