More adverse reactions following bivalent COVID-19 mRNA booster vaccine Vaccine Coronavirus Disease COVID bivalent medrxivpreprint Uni_WUE UniofOxford
By Tarun Sai LomteNov 13 2022Reviewed by Danielle Ellis, B.Sc. A recent study posted to the medRxiv* preprint server examined adverse reactions after administration of a bivalent BNT162b2 coronavirus disease 2019 vaccine booster.
Study: Bivalent BNT162b2mRNA original/Omicron BA.4-5 booster vaccination: adverse reactions and inability to work compared to the monovalent COVID-19 booster. Image Credit: Akash Sain / Shutterstock Post-vaccination adverse reactions, PRN medication and inability to work following the second COVID-19 booster administration, separated by vaccine. A) rate of adverse reactions by subcategory, B) rate of PRN medication, C) work ability restrictions. Monovalent: BNT162b2mRNA , bivalent: BNT162b2mRNA original/Omicron BA.4-5 . **: p<0.01, *: p<0.05.
Specifically, the rates of headache, body aches, tiredness, fever, chills, and local reactions were significantly higher in HCWs receiving the bivalent vaccine. Bivalent vaccine-administered HCWs reported a more frequent PRN medication use and had elevated rates of workability restrictions than monovalent vaccine-administered restrictions.
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