Physicians hope to treat children with faulty copies of their mitochondria by adding healthy maternal copies of the organelles to their blood cells.
, the organelles that serve as cells’ power plants. A research team is testing a strategy that involves soaking patients’ blood cells in a broth of healthy mitochondria from their mothers and then reinfusing them. Early signs suggest the intervention is safe and may improve the children’s health and development, and the researchers are planning a follow-up clinical trial.
Elad Jacoby, a pediatric hematology and oncology physician at Sheba Medical Center, and colleagues knew that when isolated mitochondria are mixed with cells, the organelles slip into the cells and start working. Jacoby and colleagues realized they might be able to harness this behavior to boost the number of healthy mitochondria in patients’ cells.
The researchers extracted healthy mitochondria from the mothers’ blood and HSPCs from the patients, then mixed them. “You put them in a tube, shake it, and leave it for a while,” Jacoby says. The team returned the cells to the patients’ bloodstream after 24 hours of incubation.
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