3D models reveal, at the atomicscale, how FoxH1 binds to specific points in the genome NatureComms
, was the most enriched motif in these peaks. In fact, we obtained this motif ranked with a p-value of 1.6e-42. Default options were used for both SEA 5.4.1 and STREME 5.4.1 programs.147 bp Widom DNA fragments with and without the FoxH1 binding site and the 167 bp fragment from the native Gsc promoter, containing the FoxH1 binding site were amplified by polymerase chain reaction.
on a preparative scale C-18 column. buffer A was 0.1% TFA in water, and buffer B was 90% acetonitrile and 0.1% TFA in water. Core histone purification used a gradient from 40% to 70% buffer B. Purified histones were aliquoted, lyophilized, and stored as powder at −70 °C.Core histones were individually dissolved in an unfolding buffer and quantified by A280. Histones were combined at a 1:1:0.95:0.95 molar ratio of H2A:H2B:H3.2:H4. Pooled histones were diluted to a total concentration of approximately 1.
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