We know that migraines, which are recurrent and sometimes debilitating headaches, have some genetic basis, but the link with our DNA isn't entirely clear. Newly identified genetic variants could help in developing treatments
An analysis of 1.3 million people’s genomes have revealed dozens of variations associated with migraines, which could lead to more effective treatments for the condition.
“Migraine is well known to run in families, but it has not been easy to identify a clear genetic basis for each subtype,” saysat deCODE genetics, a biopharmaceutical company in Iceland, and his colleagues have identified the genetic variations that seem to influence whether people develop migraines or not.
They found 44 gene variants associated with the condition, 12 of which have never been described before. Of these, the team found a rare variant of thegene, which helps regulate signalling between neurons, correlates with a large risk of migraine with aura, and epilepsy.After 40 years of research, scientists have uncovered what happens in the brain during a migraine and developed promising new drugs to tackle the condition.
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