Small doses of the psychotropic LSD has shown promise in recent years for its potential in rewiring the brain to be faster, happier, and more resilient.
To weigh in on the debate over the role of the placebo effect accounting for perceived improvements, de Wit and her team randomly assigned volunteers to receive a solution containing either no LSD, or small doses of 13 or 26 micrograms.
For comparison, most people experience some kind of effect from LSD once the dose exceeds around 100 micrograms. So at less than a quarter of that concentration, doses are less likely to produce obvious sensations of pleasure or changes to perception.Individuals in all three groups were given their respective dose every three to four days, sitting in a comfortable room where they could read or watch movies.
Once an hour following their prescribed test treatment, subjects filled out a mood questionnaire and had their pulse measured. They also participated in aWhen asked what drug they thought they'd received, fewer than half of the participants correctly reported LSD. Results varied widely on measures commonly used to study the hallucinogen's mind-altering effects, with impressions declining across the four sessions.
Science doesn't turn on single studies, so the question remains open as to whether small amounts of psychotropic substances like LSD might still improve moods under specific circumstances, or if it's all purely psychological. Given how much attention the idea of microdosing is getting today, researchers would be amiss if they didn't explore all the possibilities.
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