The clinical trial included over 40,000 patients with type 2 diabetes.
regardless of body mass index, and previous research has shown that insulin resistance also aids in the growth of osteoarthritis. Because of its glucose-lowering effect and safety profile, metformin is frequently the first drug used to treat diabetes mellitus and is the most commonly prescribed prescription globally for individuals with this illness.On the other hand, osteoarthritis is a chronic condition that causes severe pain and stiffness in joints.
During the clinical trial, researchers compared the results of those treated with metformin and those not given the drug and found that daily use of metformin lowers the risk of TKR or THR by up to 30 percent. Methods: We selected patients with type 2 diabetes mellitus that was diagnosed between 2000 and 2012 from the Taiwan National Health Insurance Research Database. We used prescription time-distribution matching and propensity-score matching to balance potential confounders between metformin users and nonusers. We assessed the risks of TKR or THR using Cox proportional hazards regression.
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