Meta-analysis on COVID-19 vaccine effectiveness in association with antibody titers TheLancet MetaAnalysis COVID19 Coronavirus Antibody Titers SARSCoV2
By Pooja Toshniwal PahariaMar 6 2023Reviewed by Aimee Molineux In a recent study published in Microbe, researchers performed a meta-analysis analyzing randomized controlled trials that evaluated the effectiveness of coronavirus disease 2019 vaccines and the dose-response association of humoral responses with vaccine effectiveness.
About the study In the present study, researchers assessed the effectiveness of COVID-19 vaccines in averting COVID-19 and evaluated the dosage-response relationships between humoral responses and COVID-19 vaccine effectiveness. Antibodies eBook Compilation of the top interviews, articles, and news in the last year. Download a free copy Meta-regression modeling was performed to assess the dosage-response associations of neutralizing, anti-SARS-CoV-2 spike protein immunoglobulin G , and anti-S receptor-binding domain IgG titers with vaccine effectiveness in averting symptomatic and severe SARS-CoV-2 infections.
Booster vaccinations were compared to no COVID-19 vaccinations in two trials. The combined efficacies of two-dose prime vaccination in averting asymptomatic SARS-CoV-2 infections, symptomatic SARS-CoV-2 infections, hospitalizations, severe COVID-19, and deaths were 45%, 77%, 95%, 91%, and 86%, respectively.
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