Mental health profoundly impacts inflammatory responses in the body CellCellPress PennMedicine mentalhealth health inflammatory inflammation inflammatoryboweldisease IBD
By Tarun Sai LomteMay 30 2023Reviewed by Lily Ramsey, LLM A recent study published in the Cell Journal uncovered mechanisms by which psychological stress affects bowel inflammation.
The study and findings In the present study, researchers explored the underlying mechanisms of the effects of psychological stress on enteric inflammation. Single-cell RNA sequencing of over 23,000 clusters of differentiation 45-positive leucocytes from colonic tissue of control and stressed mice identified 13 unique immune cell types.
Further, tumor necrosis factor -producing monocytes were highly accumulated in colons from stressed mice. Neutralizing TNF by a monoclonal antibody protected mice from the stress-mediated effect. The researchers speculated that the GR signaling in myeloid cells was responsible for the stress-mediated effects on IBD. Nonetheless, mice without a GR gene, nuclear receptor subfamily 3 group C member 1 , in myeloid cells were susceptible to stress effects similar to their littermate controls, suggesting an indirect result of glucocorticoids on monocytes.
The sub-clustering analysis uncovered four unique transcriptional states. One state, termed enteric glia associated with psychological stress , was exclusive to stressed conditions. Neutralizing CSF1 protein with a mAb conferred resistance to stress effects on colitis. Next, the researchers studied the neuronal compartment of the single-nucleus ENS dataset.
Using a TGF-β-neutralizing antibody prevented the transition and restored intestinal motility in stressed mice. Finally, the researchers explored the relationship between psychological stress, bowel inflammation, and dysmotility in human IBD patients.
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