Melatonin could be a potential therapy for long-COVID symptoms Melatonin LongCOVID COVID Biomol_MDPI
By Dr. Chinta SidharthanNov 9 2022Reviewed by Danielle Ellis, B.Sc. A recent review published in the journal Biomolecules discussed the potential uses of melatonin in treating brain fog and chronic fatigue syndrome or myalgic encephalomyelitis symptoms associated with long coronavirus disease .
Central nervous system sequelae of SARS-CoV-2 infection. ACE2: angiotensin-converting enzyme 2. BBB: blood–brain barrier. Related StoriesMyalgic encephalomyelitis/chronic fatigue syndrome is characterized by excessive and persistent fatigue, inability to perform physical exercise, and autonomic dysregulation. ME/CFS is also associated with disruption of circadian rhythms and the gut/mucosal barrier, mitochondrial dysfunction, and a pro-inflammatory state.
The anti-inflammatory effects of melatonin in preventing pro-inflammatory profiles or macrophages and suppressing NF-κB activation can help reverse Warburg’s effect in long COVID patients.
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