Recent studies show gut microorganisms can help people respond to immunotherapy, which...
— a severe form of skin cancer that spreads from the original tumor site to other parts of the body — benefited more from immunotherapy if they had a more diverse population of bacteria in their gut. Follow-up research found a link between a high-fiber diet and improved immunotherapy responses.
Fecal transplants are considered experimental, with a significant of infection. However, for decades they has been effective at treating Clostridium difficile, also known as C. diff, which infects the bowel and causes diarrhea and colitis. "That made us all think, OK, so if we understand that there's an association between the composition of the gut microbiome, and someone's ability to respond to immunotherapy, can we modify the gut microbiome to give many more patients the ability to respond to immunotherapy?" said Dr. Nadim Ajami, director of research for MD Anderson's PRIME-TR.
to narrow down the properties that influence the treatment. From there, the San Francisco company, formed in 2019, will use its specialized technology to engineer a synthetic material that can be manipulated and manufactured at a large scale., currently in clinical trials, for a disease known as enteric hyperoxaluria, a complication of gastrointestinal disorders.
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