Logic-gated antibody pairs that selectively act on cells co-expressing two antigens
Animal experiments were performed in compliance with the Dutch animal protection law translated from the directives and if applicable, the Code of Practice ‘animal experiments for cancer research’ and were approved by the Dutch Central Committee for animal experiments and by the local ethical committee.
Human pluripotent stem cell -humanized NSG mice were purchased from Jackson from three HPSC donors. Humanization levels were confirmed on arrival by flow cytometry , and randomization was performed based on human CD45 counts and the donors. One day before the study all animals were injected intraperitoneally with 8 mg IVIg . NSG-HIS mice were treated intravenously with antibody mixtures at a combined dose of 0.5 mg kg) and red blood cell Lysis buffer .
All fluorescently labeled antibodies specific for the cell markers used to define cell populations are listed in Supplementary Table
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