A study suggested that Asian ethnicity may predispose to the development of myeloneuropathy from recreational use of nitrous oxide.
O-related neurological side effects.
Most cases were young, in keeping with previous reports, the team said, with an average age of 22 . They noted that nitrous oxide is the second most commonly used recreational drug among 16- to 24-year-olds in the UK. Overall, three-quarters of the patients were male, though in East London this proportion dropped to two-thirds.
Over half of the patients were of Asian or Asian British ethnicity, with the highest proportion in East London , followed by Birmingham and Manchester . The researchers contrasted these numbers with population proportions of Asian or Asian British in the same areas according to the latest National Census data, at 45%, 31%, and 21%, respectively.2
O-related harm appear to be over-represented relative to the proportion of the population that is Asian or Asian British in each region," the researchers said. "This may indicate genetic susceptibility to the nerve damage caused by exposure to the gas, or other, as yet unidentified, social factors.
Follow up information was available for only 38 patients, but all bar four of them had ongoing symptoms."The possibility that genetic variation affects proteins in relevant metabolic pathways and predisposes individuals to adverse outcomes has been previously raised and should be further investigated," the researchers urged.
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