Lab-grown fish fillets has the potential to satisfy the hunger of seafood lovers and save marine animals from the dangerous effects of overfishing.
The study authors collected stem cells from a yellow croaker fish's muscle and fat tissues and cultured them in a medium. Initially, they noticed slow growth in muscle stem cells, so they studied different genetic pathways to trigger their growth.
They examined several factors that could affect the cells, “Among them, two signaling pathways, Notch and TGF-β, attracted our attention in particular. A balance between Notch and TGF-β signaling regulates the proliferation of satellite cells , and attenuation of TGF-β restores regeneration in old, injured muscle,” the researchersWhen they inhibited both these pathways, the muscle cells in the culture also started growing and multiplying at a normal pace.
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