This recent study in the Journal of Internal Medicine reveals that kidney transplantation mitigates the effects of renal aging in chronic kidney disease patients, outperforming dialysis.
By Tarun Sai LomteOct 17 2023Reviewed by Benedette Cuffari, M.Sc. In a recent study published in the Journal of Internal Medicine, researchers observe that kidney transplantation mitigates the effects of renal aging.
About the study In the present study, researchers estimate the biological age of CKD patients at stages G3 to G5 using DNA methylation , skin autofluorescence , and phenotypic age methods. The PA cohort included controls and patients with CKD at stages G3-4 and G5, whereas the DNAm cohort comprised CKD G5 patients initiating dialysis or KT and controls. The SAF cohort comprised end-stage kidney disease patients.
Related StoriesDNAm was measured, and beta values, which reflect percent methylation per locus, were calculated. DNAm age was estimated from the beta values using three DNAm clocks, including the PhenoAge, Hannum, and Horvath clocks. The SAF cohort included 199 subjects, 65.3% of whom were male. Approximately 20% of the SAF cohort had diabetes or CVD.
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