JYNNEOS vaccine shows strong effectiveness against Mpox in New York outbreak JYNNEOS Vaccine Monkeypox Outbreak VaccineCampaign Prophylaxis VaccineEffectiveness OutbreakResponse PublicHealth InfectiousDisease CDCMMWR
Bavarian Nordic’s JYNNEOS vaccine was used in the state- and nation-wide vaccination campaigns during the 2022 Mpox outbreak, which primarily affected gays, bisexuals, and males who had sex with males . As a result, health authorities prioritized postexposure prophylaxis and vaccinating high-risk individuals . However, data on JYNNEOS VE from controlled trials are limited.
The team compared JYNNEOS vaccination results among adult males with laboratory-verified Mpox diagnosed between 24 July and 31 October 2022, in New York, to those among control individuals diagnosed with primary syphilis or rectal gonorrhea and prior history of sexual intercourse with males without Mpox infection.
Reports were assessed by population health staff members and entered into the Communicable Disease Electronic Surveillance System . One-dose, two-dose, and combined estimates of JYNNEOS vaccine effectiveness were obtained. The majority of participants were unvaccinated, and 9.0% of cases were JYNNEOS vaccinees, among whom 10 individuals , 10 individuals , and two individuals had received one dose <2.0 weeks prior, one dose ≥2.0 weeks prior, and two doses, respectively. Among controls, 51 were JYNNEOS vaccinees, including 42 individuals who were diagnosed with an STI ≥2.0 weeks after receiving the initial dose or both doses .
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