The nanobody can also punch through tough brain cells. The immune system uses proteins referred to as antibodies to detect and attack invading pathogens. Mini versions of antibodies, called nanobodies — natural compounds in the blood of animals such as llamas and sharks — are being researched to tr
The nanobody can also punch through tough brain cells.
. They set out to discover a new treatment method that could target the misshapen proteins known as alpha-synuclein, which have a tendency to cluster and impede the inner workings of brain cells. New research suggests that alpha-synuclein clumps can spread from the gut or nose to the brain, accelerating disease progression.
Traditionally, nanobodies produced outside of the cell may not perform the same function within the cell. As a result, the researchers had to strengthen the nanobodies in order for them to remain stable inside a brain cell. They achieved this by genetically engineering the nanobodies to purge them of the chemical bonds that normally degrade within a cell. Tests revealed that even without the bonds, the nanobody was still able to bind to misshapen alpha-synuclein and stay stable.
“Strikingly, we induced PFFNB2 expression in the cortex, and it prevented alpha-synuclein clumps from spreading to the mouse brain’s cortex, the region responsible for cognition, movement, personality, and other high-order processes,” says Ramhari Kumbhar, Ph.D., the co-first author, a postdoctoral fellow at the Johns Hopkins University School of Medicine.
Brasil Últimas Notícias, Brasil Manchetes
Similar News:Você também pode ler notícias semelhantes a esta que coletamos de outras fontes de notícias.
Tokina's Mini Pieni II Toy Camera Actually Takes Tiny Photos and VideosKenko Tokina's Pieni II toy digital camera is small enough to be held with two fingers and takes tiny 1.3-megapixel photos and videos.
Consulte Mais informação »
Kendall Jenner's Mini Dress and Heeled Leather Boots Are What Fall Fashion Dreams Are Made ofThis look is crazy cute and super easy to recreate.
Consulte Mais informação »
Get $364 Off This Refurbished Apple iPad Mini 4Get $364 off this refurbished Apple iPad Mini 4!
Consulte Mais informação »
Mini Celebrates 20 Years In The U.S. With Special Red, White, And Blue Anniversary Editions | CarscoopsMini Celebrates 20 Years In The U.S. With Special Red, White, And Blue Anniversary Editions | Carscoops carscoops
Consulte Mais informação »
Mini Cooper S Special Edition Ditches Union Jack in Favor of the Stars and StripesMini USA is celebrating its 20th anniversary in the U.S. with American-flag-themed decor on a Mini Cooper S that is of course available in red, white, or blue.
Consulte Mais informação »
Letter: Do we really want a Trump mini-me representing our state?Letter: 'Maybe people should question the claims made by Republicans since they are seldom truthful. We might have a better government.'
Consulte Mais informação »