Jimmy Garoppolo throws for 4 TDs as San Francisco 49ers rout Arizona Cardinals in Mexico City

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Jimmy Garoppolo throws for 4 TDs as San Francisco 49ers rout Arizona Cardinals in Mexico City
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Jimmy Garoppolo threw four touchdown passes as the San Francisco 49ers blew out the Arizona Cardinals in Mexico City.

Mackenzie Salmon 'overreacts' to the biggest NFC storylines from Week 11 action in the NFL.MEXICO CITY — Jimmy Garoppolo threw four touchdown passes, including two each to Brandon Aiyuk and George Kittle, and the San Francisco 49ers won their third straight game by blowing past the Arizona Cardinals 38-10 on Monday night in Mexico City.

It was a tight game through much of the first half, but the 49ers pulled away in the second half, jumping ahead 24-10 early in the third quarter on a nifty end-around play. Samuel took the pitch and sprinted 39 yards, weaving through the Cardinals defense on his way to the end zone. McCoy finished 24 of 34 passing for 218 yards and an interception. The 49ers hit him hard multiple times, connecting for three sacks

The 49ers responded early in the second when Garoppolo hit Aiyuk over the middle for a 7-yard touchdown, capping a nine-play, 82-yard drive. San Francisco intercepted McCoy on the ensuing drive after a pass bounced off James Conner’s hand and was snatched out of the air by Jimmie Ward.

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