Is translocator protein distribution volume elevated in the brain after acute COVID-19 infection with sequelae of depressive and cognitive symptoms? JAMAPsych translocator protein distribution brain covid COVID19 SARSCoV2
By Bhavana KunkalikarJun 5 2023Reviewed by Lily Ramsey, LLM In a recent study published in the JAMA Psychiatry Journal, researchers discuss the occurrence of neuroinflammation after coronavirus disease 2019 characterized by cognitive and depressive symptoms.
In neuropsychiatric diseases characterized by brain inflammation, translocator protein total distribution volume binding is mainly associated with activated microglia and astroglia. In general, it is primarily present in endothelial cells. Related StoriesThe main inclusive criteria for COVID-DC patients was the diagnosis of a novel major depressive episode within three months of acute COVID-19, as documented by the Structured Clinical Interview for DSM-5-Research Version.
The study's primary measures were motor speed using the overall severity of MDE estimated according to the 17-item Hamilton Depression Rating Scale score, finger-tapping test, and self-perceived deficits in cognitive functioning calculated as per the Cognitive Failures Questionnaire score.
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