Researchers evaluated adiposity markers to determine the marker with the most consistent association mortality.
By Dr. Chinta SidharthanSep 25 2023Reviewed by Lily Ramsey, LLM In a recent study published in the JAMA Network Open Journal, researchers evaluated adiposity markers such as waist-to-hip ratio , fat mass index , and body mass index , to determine the marker with the most consistent and strongest association with cause-specific and all-cause mortality.
Furthermore, observational studies have shown that other adiposity markers that consider fat distribution and body composition, such as WHR and FMI, have stronger associations with disease and mortality risk than BMI. The researchers believe that an optimal measure or marker of clinical adiposity should not only show a strong association with adverse outcomes such as disease and mortality but also be easy to measure and consistent across a wide range of body compositions.
FMI is calculated as the ratio of fat mass to height, while WHR is a surrogate measure for abdominal adiposity. The strength of the association between these adiposity markers and mortality was assessed using linear Mendelian randomization. In contrast, non-linear Mendelian randomization was used to assess the consistency of the adiposity markers.
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