Scientists identify a single chemical that someday could help end baldness and speed wound healing.
The power of TGF-β depends on its intensity, and the researchers describe the chemical’s mechanism as a “threshold-like switch”: Too much of the chemical causes the cell to die, causing hair to fall out. At the same time, lesser doses allow the cell to grow and divide.
Being able to precisely control TGF-β levels and understand how the chemical interacts with specific genes could allow future scientists to stimulate hair growth, according toStem cells are like blank canvases – the body can program them to turn into other types of cells. Within hair follicles, stem cells play a unique role that captured the researchers’ attention: Hair follicles are the only organ in the human body that constantly regenerates, even without injury, according to researchers.
“Even when a hair follicle kills itself, it never kills its stem cell reservoir. When the surviving stem cells receive the signal to regenerate, they divide, make new cells, and develop into a new follicle,” Wang said. The bald truth is that by focusing on these unique regenerative cells, researchers hope to promote complete wound healing, which requires hair regeneration.
“Potentially, our work could offer something to help people suffering from a variety of problems,” said Wang.Biophysical JournalUniversity of California, Riverside: “The chemical controlling life and death in hair follicles.”
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