Investigating the relationship between red blood cells and the clinical course of COVID-19 in children SciReportstudresden_de redbloodcells RBC covid COVID19 SARSCoV2
By Neha MathurJun 20 2023Reviewed by Lily Ramsey, LLM In a recent study published in Scientific Reports, researchers performed the ImmunCoviDD19-study among school students from urban Dresden and rural Saxony in Germany between June 24 and July 16, 2021.
Background RBCs are one of the key players in microcirculation, hypoxemia, and tissue oxygenation under physiological conditions. Severe COVID-19 triggers microcirculation as a compensatory response. Overall, COVID-19-induced changes in RBC properties might impact microcirculation, heightening the risk of pulmonary embolism and micro thrombosis.
Finally, they performed partial correlations between either group by SARS-CoV-2-serostatus by adding age and gender as confounding variables. They controlled type 1 errors and adjusted p-values using Holm-Bonferroni correction for multiple comparisons. The IQR of RBC deformation tended to be lower but did not withstand the Holm-Bonferroni correction. However, the median RBC area was similar in SARS-CoV-2-seropositive and seronegative participants.
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