'Low-level, invisible inflammation, simmering quietly in the blood of ostensibly healthy people, may be a common thread running through nearly all diseases,' writes Dr. Shilpa Ravella
—is unlikely to be serendipitous. The intricate link between inflammation and modern chronic diseases is rooted in our evolutionary history. In order to survive infections, famine, and other dangers in brutish ancestral times, we developed hyperactive immune systems and insulin-resistant bodies adept at storing fat. But our modern environment has been markedly transformed, from the food we eat to the air we breathe, how we move and more.
Managing energy and defending the body against infections are both crucial for survival, and coevolved. Fat cells—which are known to play a part in metabolism—and immune cells derive from the same ancestral cell, and share many roles. An excess of fatty tissue, particularly the “visceral fat” that wraps around abdominal organs, acts like immune organ, producing a slew of inflammatory molecules.
The idea that inflammation may be a shared biological mechanism between many of our modern chronic diseases fosters a new understanding of human health. It compels us to consider diagnosing, preventing and treating these diseases in concert rather than only in piecemeal fashion. Doing this means delving into the root causes of hidden inflammation, which are largely lifestyle factors, including our diet.
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